Testosterone and Quality of Life in Transgender and Gender-Diverse Adults Seeking Masculinization: A Secondary Analysis of a Randomized Clinical Trial

Abstract

Introduction: Testosterone treatment is a necessary component of gender affirmation for some transgender and gender-diverse adults seeking masculinization. We have previously demonstrated1 that early access to testosterone therapy, compared with commencement following a standard care waiting list of 3 months, reduces gender dysphoria, depression, and suicidality in transgender and gender-diverse adults. Observational studies2,3 have demonstrated associations between testosterone commencement and improvements in quality of life; however, no randomized clinical trial has been performed that we know of. We aimed to examine the outcomes of early access to testosterone therapy, compared with no t..